If you have recently updated Illustrator or have installed a fresh copy and you receive an error when opening. The latest version of ArcGIS Maps for Adobe Creative Cloud plugin (2.2.1) is compatible with older version of Illustrator version 25.0.1. Recent updates to Illustrator specifically version 25.1 onwards have resulted in a need for plugin developers to patch their Mac builds to include a new method for building Mac OS based plugins.
Update: New version v2.2.2 (for macOS only) addresses this compatibility.
